IDAC-Dose 2.1, an internal dosimetry program for diagnostic nuclear medicine based on the ICRP adult reference voxel phantoms
نویسندگان
چکیده
BACKGROUND To date, the estimated radiation-absorbed dose to organs and tissues in patients undergoing diagnostic examinations in nuclear medicine is derived via calculations based on models of the human body and the biokinetic behaviour of the radiopharmaceutical. An internal dosimetry computer program, IDAC-Dose2.1, was developed based on the International Commission on Radiological Protection (ICRP)-specific absorbed fractions and computational framework of internal dose assessment given for reference adults in ICRP Publication 133. The program uses the radionuclide decay database of ICRP Publication 107 and considers 83 different source regions irradiating 47 target tissues, defining the effective dose as presented in ICRP Publications 60 and 103. The computer program was validated against another ICRP dosimetry program, Dose and Risk Calculation (DCAL), that employs the same computational framework in evaluation of occupational and environmental intakes of radionuclides. IDAC-Dose2.1 has a sub-module for absorbed dose calculations in spherical structures of different volumes and composition; this sub-module is intended for absorbed dose estimates in radiopharmaceutical therapy. For nine specific alpha emitters, the absorbed dose contribution from their decay products is also included in the committed absorbed dose calculations. RESULTS The absorbed doses and effective dose of 131I-iodide determined by IDAC-Dose2.1 were validated against the dosimetry program DCAL, showing identical results. IDAC-Dose2.1 was used to calculate absorbed doses for intravenously administered 18F-FDG and orally administered 99mTc-pertechnetate and 131I-iodide, three frequently used radiopharmaceuticals. Using the tissue weighting factors from ICRP Publication 103, the effective dose per administered activity was estimated to be 0.016 mSv/MBq for 18F-FDG, 0.014 mSv/MBq for 99mTc-pertechnetate, and 16 mSv/MBq for 131I-iodide. CONCLUSIONS The internal dosimetry program IDAC-Dose2.1 was developed and applied to three radiopharmaceuticals for validation against DCAL and to generate improved absorbed dose estimations for diagnostic nuclear medicine using specific absorbed fraction values of the ICRP computational voxel phantoms. The sub-module for absorbed dose calculations in spherical structures 1 mm to 9 cm in diameter and different tissue composition was included to broaden the clinical usefulness of the program. The IDAC-Dose2.1 program is free software for research and available for download at http://www.idac-dose.org .
منابع مشابه
Development of Iranian Adult Female Reference Phantom for Internal Dosimetry Calculations
Estimation of organ doses in diagnostic and therapeutic nuclear medicine procedures is an area of particular concern for radiation protection, in all over the world. The stylized computational phantoms have contributed significantly to radiation dosimetry in nuclear medicine; however, their simplified treatment of human anatomy is being criticized. Due to the fact that the ICRP adult reference ...
متن کاملDevelopment of Prototype Iranian male pelvic phantom for internal dosimetry
Introduction: Existing phantoms have been constructed based on Caucasian, non-Caucasian and race-specific datasets. According to previous studies made efforts to present Korean- specific phantoms and Chinese female phantom based on CVH dataset due to compare the resulting internal dosimetry with the Caucasian based data showed possible racial difference in human anatomy between ...
متن کاملInternal dosimetry of radioiodine using ICRP reference phantoms and updated biokinetic model
The purpose of this study is to estimate internal dose to human body due to administration of I-131 using new biokinetic model of iodine. In this respect, we used international commission on radiological protection (ICRP) adult reference phantoms. Monte Carlo calculations were performed using MCNPX 2.6 code. The average dose to target organ per disintegration inside source organ, namely S facto...
متن کاملDeveloping the Adult Male ICRP Phantom and Evaluation the Absorbed Dose Received By Critical Organs in Head and Neck Region during the Radiotherapy of Eye Cancer
Introduction Accurate estimation of the absorbed dose in radiosensitive organs, located away from the target volume during radiotherapy, is one of the main reasons for the development of reference phantoms. The International Commission on Radiological Protection (ICRP) reference phantoms can provide a more realistic view of the human anatomy in comparison with the previously used mathematical p...
متن کاملDevelopment of a 9-months pregnant hybrid phantom and its internal dosimetry for thyroid agents
As a consequence of fetal radiosensitivity, the estimation of internal dose received by a fetus from radiopharmaceuticals applied to the mother is often important in nuclear medicine. A new 9-months pregnant phantom based on magnetic resonance (MR) images tied to the International Commission on Radiological Protection (ICRP) reference voxel phantom has been developed. Maternal and fetal organs ...
متن کامل